The sector is the leader in the region's economy. For 10 months of 2022, the share of the manufacturing industry amounted to 67.2%. The leading enterprises in this sector are Kazzinc LLP, Ust-Kamenogorsk Titanium and Magnesium Plant JSC, Ulba Metallurgical Plant JSC. The enterprises manufacture the main precious and non-ferrous metals: lead, zinc, copper, refined gold and silver, as well as titanium, tantalum, fuel for nuclear power plants.  

Kazzinc LLP is a major fully integrated zinc producer with considerable copper, precious metals and lead credits - a total of 23 types of finished products. The product types include metal zinc, refined lead, refined silver, cathode copper, and other related products. The company is the largest gold producer in the Republic of Kazakhstan. The main enterprises of the company are located on the territory of the Republic of Kazakhstan, most of all in East Kazakhstan region. The company was founded in 1997. The general investor is Glencore International AG.

Ulba Metallurgical Plant JSC is one of the worldwide recognized manufacturers of uranium, beryllium, tantalum and niobium products for the needs of nuclear energy, electronics, metallurgical industry and other sectors. Since 1997, the enterprise has been incorporated into Kazatomprom National Atomic Company JSC. The enterprise includes large metallurgical productions - uranium, beryllium and tantalum, as well as a developed infrastructure of auxiliary departments. The manufacturer of uranium fuel components for nuclear power plants is uranium production. Uranium production products (uranium dioxide powders and fuel pellets) are certified by the largest fuel producers of the world. The products are exported to the countries of North America, Europe and Asia. The beryllium production is also unique, with a full cycle, ranging from the processing of ore concentrates to the production of a wide range of products based on beryllium and its alloys. Finished products are sold to the countries of the European Union, the Russian Federation, the USA, China and Japan. Tantalum production of the plant is the only one in the CIS and one of the four worldwide largest ones with a full production cycle ranging from raw materials processing to finished tantalum-niobium products with specified quality parameters. Among the partners of UMP tantalum production are well-known companies from the USA, Russia, France, Germany and Japan.   

Ust-Kamenogorsk Titanium and Magnesium Plant JSC is one of the largest worldwide vertically integrated industry enterprises. It includes all technological stages ranging from the extraction of raw materials to the production of finished products. The production structure of the plant includes 5 main and 6 auxiliary shops, as well as subsidiaries and joint ventures. The plant's products are certified by all world aerospace enterprises. Kazakhstan titanium occupies 16% of the world market and is used in shipbuilding, medicine, oil and chemical industries. Its partners are companies such as Boeing, Airbus, Nippon Steel, SNECMA, General Electric and many others.